Useful Tips

How to use isotrexin gel


Dermatotropic combined drug. Application: acne. Price from 1880 rub.

Analogs: Bezugrey, Deriva S, Retin A. More about analogues, their prices, and whether they are substitutes, you can find out at the end of this article.

Today we’ll talk about Isotrexin gel. What is the remedy, how does it affect the body? What are the indications and contraindications? How and in what doses is it used? What can be replaced?

Side effects

Allergic reactions: eczema, peeling of the skin, irritation, tingling and burning sensation.

Sometimes: photosensitivity - increased skin sensitivity to ultraviolet and visible light.

If side effects occur, the use of the gel should be stopped immediately until they disappear completely. Then the therapy can be continued.

Drug interaction

The combined use of Isotrexin with drugs of the keratolytic, exfoliative retinoid series is prohibited.

The action of Isotrexin weakens the synchronous administration of tetracyclines, and local application of GCS.

You can replace the gel:

Before using a similar drug for acne therapy, you should consult your doctor.

Pharmacodynamics and pharmacokinetics

Included in the gel isotretinoin, in its structure and farm. activity similar to vitamin A. Retinol in turn, responsible for cell growth and division epithelium, with regular use, the substance is able to inhibit the activity of the sebaceous glands, reduce inflammation, reduce the process of sebum secretion and the activity of bacteria that cause acne.

Erythromycin belongs to the groupmacrolide antibiotics. Substance by exposure to ribosomes bacteria inhibits synthesis polypeptides and prevents their reproduction. The drug reduces the population Propionibacterium acnes, inflammatory mediators cease to stand out. It is known that this antibiotic may lead to development superinfection and strainsresistant to its action. However, when combined erythromycin with isotretinoin the drug becomes effective and to resistant strains.

Isotrexin quite active in the treatment of inflammatory and non-inflammatory skin lesions.

The active substance of the drug is not exposed to systemic absorption.

Instructions for Isotrexin (method and dosage)

Before applying the gel, the surface of the skin must be well cleaned, remove makeup, wash hands.

A small amount of gel is applied in a thin layer on the affected area of ​​the skin. It is necessary to apply the drug not only directly on acne, but also on adjacent areas of the skin.

The frequency of use of the drug is 1-2 times a day.

The course of treatment, as a rule, is from 1.5 to 2 months.

After applying the product, you can apply light makeup.

Precautions should be observed during drug therapy. Do not let the medicine get into the eyes or mucous membranes. It is not recommended to violate the regimen of use and dosage of the drug in order to avoid the development of undesirable side reactions.


It is recommended to avoid simultaneous application of gel with oxidizing agents (benzoyl peroxide), this reduces the effectiveness of therapy with the drug. If necessary, both drugs can be applied after a period of time, for example, one in the morning and the other in the evening.

special instructions

Since the medicine may accumulate in the upper layers epidermis, it is not recommended to combine with other acne medications.

If during treatment severe irritation appears on the skin or dermatitis, therapy must be interrupted for a while. If after a break the reaction to the action of the gel persists, then the medicine must be replaced.

Avoid contact of the gel with mucous membranes, eyes, eczematous skin lesions, cumulation of medication in the folds of the skin, on the wings of the nose. Particular care should be taken when treating sensitive neck skin.

It is necessary to protect the treated areas of the skin from ultraviolet radiation in order to avoid the appearance of undesirable reactions.

In very rare cases, under the influence of the agent, it can develop pseudomembranous colitis. At the first sign of a disease (abdominal pain, diarrhea) treatment must be discontinued.

Reviews on Isotrexin

Medicine helps fight acne and acne. After completing the course, many people forget about such problems forever. Judging by the reviews of the Isotrexin gel, it dries the skin very much and often causes allergic reactions.

Also, at the beginning of treatment, the drug can cause an exacerbation. Many note the effectiveness of the drug, it is enough to apply it in a very thin layer and exclusively on the affected areas.

Isotrexin gel: dermatologist reviews

The original instructions for the drug say that the main indication for use will be the treatment of acne. Recall that acne is nothing but fatty plugs in the pores of the skin (located at the mouth of the hair follicles), consisting of the fat secretion of the sebaceous glands and desquamated epithelial cells of the hair follicle.

0.05% Isotretinoin, which is part of the drug, perfectly reduces the secretion of fat secretion by the sebaceous glands, and also normalizes the keratinization processes of the hair follicle epithelium, which will lead to a sharp decrease in the number of desquamated epithelial cells in the follicle lumen. All this will really prevent the formation of fatty plugs (blackheads).

But! The composition of the drug also includes the antibiotic erythromycin in an effective therapeutic concentration of 2.0%, which is necessary to suppress pathogenic microflora, due to which acne is transformed into acne (in the form of papules or purulent pustules). Creams and gels with this antibiotic are actively prescribed by dermatologists only for the treatment of acne that has already arisen.

findings : this drug will be very effective in the combined form of acne, i.e. when you have acne and acne at the same time. But it should not be used if you only have acne, but no acne. The latter is due to the fact that microflora is gradually getting used to any antibiotics, and the moment may come when the bacteria (causing acne) become much more aggressive and insensitive to antibiotics.

And it is not necessary to apply, including if necessary, the prevention of the appearance of purulent acne. To prevent the appearance of acne, it is best to use not antibacterial drugs at all, but best of all - antimicrobial gels and lotions based on the benzoyl peroxide antiseptic.

Release form and composition

Isotrexin is produced in the form of a gel for external use: soft, pale yellow (6, 25, 30, 40 or 50 g each in aluminum tubes, 1 tube in a cardboard bundle).

1 g contains active substances:

  • Isotretinoin - 0.5 mg,
  • Erythromycin - 20 mg.

Auxiliary components: butylhydroxytoluene, hyprolose, ethanol.


  • Children under 12 years old
  • Hypersensitivity to the drug.

Despite the slight percutaneous absorption of isotretinoin, the use of the Isotrexin gel is contraindicated in cases of established or planned pregnancy.

Since it is not known whether the components of the product with breast milk are excreted, the drug should not be prescribed during breastfeeding (lactation).

The price of Isotrexin in pharmacies

The price of Isotrexin in pharmacies was 415 rubles (for a tube of 30 g), but currently it is not on sale.

Education: First Moscow State Medical University named after I.M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace the official instructions. Self-medication is dangerous to health!

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